β-C(sp2)–H alkylation of enamides using xanthate chemistry
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چکیده
منابع مشابه
FeCl3-promoted alkylation of indoles by enamides.
An efficient iron-promoted alkylation of indoles with enamides has been accomplished under mild reaction conditions. The reaction proceeded with remarkable regioselectivity leading exclusively to substitution by indoles at α-position of enamides.
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Direct alkylation of indoles and amines by tertiary enamides for the synthesis of pharmaceutically active 2-oxo-1-pyrrolidine analogues was described. With only a 0.5 mol% catalyst loading, molecular iodine was demonstrated to be efficiently enough to promote the reaction under neat condition. Only Markovnikov addition product was obtained indicating that the reactions proceeded with excellent ...
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ژورنال
عنوان ژورنال: New Journal of Chemistry
سال: 2020
ISSN: 1144-0546,1369-9261
DOI: 10.1039/d0nj01209b